On the Key Role of Secondary Lymphoid Organs in Antiviral Immune
نویسندگان
چکیده
From the * Institute of Experimental Immunology, Department of Pathology, University Hospital of Zürich, 8091 Zürich, Switzerland; ‡ Laboratory for Special Techniques, Department of Pathology, University of Zürich, 8091 Zürich, Switzerland; § Howard Hughes Medical Institute and Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, Missouri 63110; and Molecular Biology Department, Research Laboratories, Nippon Shinyaku Co., Ltd., Nishioji-Hachijo, Minami-ku, Kyoto 601, Japan
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On the Key Role of Secondary Lymphoid Organs in Antiviral Immune Responses Studied in Alymphoplastic (aly/aly) and Spleenless (Hox11−/−) Mutant Mice
The role of the spleen and of other organized secondary lymphoid organs for the induction of protective antiviral immune responses was evaluated in orphan homeobox gene 11 knockout mice (Hox11(-/-)) lacking the spleen, and in homozygous alymphoplastic mutant mice (aly/aly) possessing a structurally altered spleen but lacking lymph nodes and Peyer's patches. Absence of the spleen had no major ef...
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